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Pulse vaccination strategy
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Pulse vaccination strategy : ウィキペディア英語版
Pulse vaccination strategy

The pulse vaccination strategy is a method used to eradicate an epidemic by repeatedly vaccinating a group at risk, over a defined age range, until the spread of the pathogen has been stopped. It is most commonly used during measles and polio epidemics to quickly stop the spread and contain the outbreak.〔Nokes, DJ., Swinton, J. The control of childhood viral infections by pulse vaccination.IMA J Math Appl Med Biol. 1995;12(1):29-53.〕〔Nokes, DJ., Swinton, J. Vaccination in pulses: a strategy for global eradication of measles and polio?Trends Microbiol. 1997 Jan;5(1):14-9.〕
Where T= time units is a constant fraction p of susceptible subjects vaccinated in a relatively short time. This yields the differential equations for the susceptible and vaccinated subjects as:
: \frac = \mu N - \mu S - \beta \frac S, S(n T^+) = (1-p) S(n T^-) n=0,1,2,\dots
: \frac = - \mu V, V(n T^+) = V(n T^-) + p S(n T^-) n=0,1,2,\dots
It is easy to see that by setting one obtains that the dynamics of the susceptible subjects is given by:
: S^
*(t) = 1- \frac
and that the eradication condition is:
: R_0 \int_^ < 1
== See also ==

*Critical community size
*Epidemic model
*Pulse Polio
*Vaccine-naive
*Herd immunity
*Ring vaccination

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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